Fluorinated or per-fluorinated aliphatic carboxylic acids tend to be strong acids, and more hydrophobic than the parent compounds. Acetic acid pKa is 4.75 whilst trifluoro-acetic acid the pka is -0.3. In general terms they have a similar chemical reactivity. Often higher metabolic stability is achieved by introducing a fluorine atom. At EnamineStore there are a wide range of fluorinated carboxylic acids, including mono, di, and trifluoro-methyl analogues, perfluoromethoxy derivatives, along with fluorinated cyclic systems. Have a look at our suggestions below: