Diamine scaffolds are particularly useful templates for lead generation and lead optimization. Incorporation of such scaffolds can impart restricted confirmations with enhanced desirable physiochemical profile of the resulting products. Moreover these scaffolds have a proven track record in target class areas such as GCPRs. At the EnamineStore you will find readily available examples of diamine scaffold encompassing aliphatic ring systems including spiro, bridged and fused examples with appropriate ‘protection’ of one of the amine groups. Take a look below for representative examples.