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Pioglitazone hydrochloride

U72107A

Technical Data

Chemical name:Pioglitazone hydrochloride
Formula:C19H21ClN2O3S
Molecular weight:392.9
CAS number:112529-15-4
SMILES:Cl.CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1

Cat. No. BRC0868

BRC0868

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Antidiabetic   

Target:

Enzymes    Amine oxidase    Nuclear Receptors (nuclear hormone receptors)    Peroxisome proliferator-activated receptor (PPAR)   

Description:

Pioglitazone hydrochloride is a selective agonist at peroxisome proliferator activated receptor gamma (PPARγ) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. It is used as an antidiabetic.

Targets:Peroxisome proliferator-activated receptor gamma, Peroxisome proliferator-activated receptor delta, Peroxisome proliferator-activated receptor alpha, Amine oxidase [flavin-containing] B
References:
1. J. Biol. Chem. 1995; 270(22), 12953-6.; 
2. Eur. J. Pharmacol. 2017; 799, 160 - 170.; 
3. Curr Top Med Chem. 2012; 12, 6, 548 - 584.;