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Telmisartan

BIBR 277, BIBR 277SE, Kinzalmono, Micardis, Pritor, Telday

Technical Data

Chemical name:Telmisartan
Formula:C33H30N4O2
Molecular weight:514.6
CAS number:144701-48-4
SMILES:CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O)-c1nc2ccccc2n1C

Cat. No. BRC0679

BRC0679

Prices

1.0 mg $ 55.0
2.0 mg $ 56.0
5.0 mg $ 59.0
10.0 mg $ 78.0
20.0 mg $ 93.0
25.0 mg $ 100.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Antihypertensive    Cardiovascular   

Target:

G-Protein-Coupled Receptors (GPCRs)    Angiotensin receptor    Nuclear Receptors (nuclear hormone receptors)    Peroxisome proliferator-activated receptor (PPAR)    Multidrug Transporter Inhibitors    P-glycoprotein/ABCB1   

Description:

Telmisartan is a non-peptide AT1 angiotensin receptor antagonist (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Telmisartan also have PPAR-gamma agonistic properties (EC50 = 4 nM) that could potentially confer beneficial metabolic effects.

Targets:Type-1 angiotensin II receptor, Peroxisome proliferator-activated receptor gamma
References:
1. Drugs. 2001; 61(10):1501-29.; 
2. Clin Ther. 2002 Oct; 24(10):1484-501.; 
3. Br J Pharmacol. 2007; 151, 7, 952.;