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Rosiglitazone maleate

Avandia, Brl-49653, Rosiglizole, BRL49653,

Technical Data

Chemical name:Rosiglitazone maleate
Formula:C22H23N3O7S
Molecular weight:473.5
CAS number:155141-29-0
SMILES:OC(=O)\C=C/C(O)=O.CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1

Cat. No. BRC0016

BRC0016

Prices

1.0 mg $ 83.0
2.0 mg $ 85.0
5.0 mg $ 90.0
10.0 mg $ 117.0
20.0 mg $ 150.0
25.0 mg $ 170.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Therapeutic areas:

Antidiabetic   

Target:

Enzymes    Ligases    Nuclear Receptors (nuclear hormone receptors)    Peroxisome proliferator-activated receptor (PPAR)   

Description:

Rosiglitazone acts as a highly selective and potent agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR-gamma receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. In this way, rosiglitazone enhances tissue sensitivity to insulin.

Targets:Peroxisome proliferator-activated receptor gamma, Long-chain-fatty-acid--CoA ligase 4
References:
1. Endocrinol Metab. 2004 Jun; 89(6):2728-35.; 
2. N Engl J Med. 2006 Dec 7; 355(23):2427-43.;