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GW 9662

2-chloro-5-nitrobenzanilide

Technical Data

Chemical name:GW 9662
Formula:C13H9ClN2O3
Molecular weight:276.7
CAS number:22978-25-2
SMILES:[O-][N+](=O)c1ccc(Cl)c(c1)C(=O)Nc1ccccc1

Cat. No. BRC0310

BRC0310

Prices

1.0 mg $ 82.0
2.0 mg $ 84.0
5.0 mg $ 89.0
10.0 mg $ 116.0
20.0 mg $ 139.0
25.0 mg $ 151.0

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Biological activity

It belongs to next groups of Bioreference compounds:
Target:

Nuclear Receptors (nuclear hormone receptors)    Peroxisome proliferator-activated receptor (PPAR)   

Description:

Selective PPARγ antagonist (IC50 values are 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively). Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range (1-2 μM. Anticancer, inhibits growth of human mammary tumor cell lines.

Targets:PPARγ, PPARα, PPARδ,
References:
1. Kidney Int. 2005 Aug; 68(2):529-36.; 
2. Br J Pharmacol. 2004 Dec; 143(8):933-7.; 
3. Biochemistry. 2002 May 28; 41(21):6640-50.;